CHARLES W. LEFFLER, Ph.D.

Professor

Department of Physiology

The University of Tennessee College of Medicine

Address

The University of Tennessee Health Science Center

309 Nash Research Building

894 Union Avenue

Memphis, TN 38163

Tel: (901) 448-7122; Fax: (901) 448-7126;

Education

Ph.D. Institution: University of Florida, Department of Zoology

Postdoctoral: University of Florida, Department of Physiology

Research Interests

Research in the laboratory concentrates on newborn cardiovascular regulation, with particular emphasis on control of cerebral circulation. The primary focus of this research involves autocrine/paracrine control of the newborn cerebral microvasculature during physiologically stressful and pathological situations, and the cellular mechanisms involved in such control.

Links

Physiology - Charles Leffler

Recent Publications

• Kanu A, Leffler CW. Roles of glia limitans astrocytes and carbon monoxide in adenosine diphosphate-induced pial arteriolar dilation in newborn pigs. Stroke. 2009 Mar;40(3):930-5. Epub 2009 Jan 22. PMID: 19164779
• Basuroy S, Bhattacharya S, Leffler CW, Parfenova H. Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells. Am J Physiol Cell Physiol. 2009 Mar;296(3):C422-32. Epub 2008 Dec 31. PMID: 19118162
• Narayanan N, Leffler CW, Daley ML. Assessment of cerebrovascular resistance with a model of cerebrovascular pressure transmission. Med Eng Phys. 2009 Mar;31(2):254-60. Epub 2008 Aug 8. PMID: 18693128
• Narayanan N, Leffler CW, Daley ML. Influence of hypercapnic vasodilation on cerebrovascular autoregulation and pial arteriolar bed resistance in piglets. J Appl Physiol. 2008 Jul;105(1):152-7. Epub 2008 Apr 24. PMID: 18436696
• Parfenova H, Leffler CW. Cerebroprotective functions of HO-2. Curr Pharm Des. 2008;14(5):443-53. Review. PMID: 18289071
• Daley ML, Narayanan N, Leffler CW, Eide PK. Stroke with subarachnoid hemorrhage: assessment of cerebrovascular pressure regulation and simulated cerebrovascular resistance. Acta Neurochir Suppl. 2008;102:321-5. PMID: 19388338

view complete list of references (pubmed link)