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EDWARD CHAUM, M.D., Ph.D.
- Plough Foundation Professor of Retinal Diseases
Associate Professor
- Department of Ophthalmology
- Department of Pediatrics
- Department of Anatomy and Neurobiology
- The University of Tennessee College of Medicine
Address
- The University of Tennessee Health Science Center
- Hamilton Eye Institute
- 930 Madison Avenue, Suite 731
- Memphis, TN 38163
- Tel: (901) 448-5975;
Education
- Ph.D. Institution: Department of Cell Biology and Genetics, Cornell Graduate School of Medical Sciences
- M.D. Institution: Cornell University Medical College
Research Interests
The focus of the basic science research program in our laboratory is in five major areas:
- Translational research in the development and application of gene therapy to the treatment of retina degenerative diseases,
- Tissue engineering approaches to understanding and modulating the growth, aging and wound healing responses of ocular retinal pigment epithelial cells (RPE),
- Molecular analyses of retinal pigment epithelial cell responses to oxidative stress,
- Characterization of a newly discovered IGF binding protein regulatory system in the RPE, and
- Tele-ophthalmology and automated diagnostics
Other areas of active research include collaborations on numerous pilot basic science and clinical projects with investigations into:
- Genomic analysis of RPE gene expression,
- The role of CD81 in proliferative vitreoretinopathy, wound healing and retinal detachment,
- The role of Arf gene mutations in the developmental eye anomaly persistent fetal vasculature,
- Electrochemical quantification of blood metabolites and drugs, and
- Nanotechnology applications in retinal surgery, and
- Clinical research studies.
Links
- Ophthalmology - Edward Chaum
Recent Publications
- Chaum E, Yin J, Yang H, Thomas F, Lang JC.
Quantitative AP-1 gene regulation by oxidative stress in the human retinal
pigment epithelium.
J Cell Biochem. 2009 Sep 30; [Epub ahead of print]
PMID: 19795388
- Diabetes Control and Complications Trial/Epidemiology of Diabetes
Interventions and Complications (DCCT/EDIC) Research Group; Nathan DM, Zinman B,
Cleary PA, Backlund JY, Genuth S, Miller R, Orchard TJ.
Modern-day clinical course of type 1 diabetes mellitus after 30 years'
duration: the diabetes control and complications trial/epidemiology of diabetes
interventions and complications and Pittsburgh epidemiology of diabetes
complications experience (1983-2005).
Arch Intern Med. 2009 Jul 27;169(14):1307-16.
PMID: 19636033
- Tobin KW, Abramoff MD, Chaum E, Giancardo L, Govindasamy V, Karnowski TP,
Tennant MT, Swainson S.
Using a patient image archive to diagnose retinopathy.
Conf Proc IEEE Eng Med Biol Soc. 2008;2008:5441-4.
PMID: 19163948
- Karnowski TP, Govindasamy V, Tobin KW, Chaum E, Abramoff MD.
Retina lesion and microaneurysm segmentation using morphological reconstruction
methods with ground-truth data.
Conf Proc IEEE Eng Med Biol Soc. 2008;2008:5433-6.
PMID: 19163946
- Giancardo L, Abramoff MD, Chaum E, Karnowski TP, Meriaudeau F, Tobin KW.
Elliptical local vessel density: a fast and robust quality metric for retinal
images.
Conf Proc IEEE Eng Med Biol Soc. 2008;2008:3534-7.
PMID: 19163471
- Chaum E, Karnowski TP, Govindasamy VP, Abdelrahman M, Tobin KW.
Automated diagnosis of retinopathy by content-based image retrieval.
Retina. 2008 Nov-Dec;28(10):1463-77.
PMID: 18997609
view complete list of references (pubmed link)
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