Edward Chaum, M.D., Ph.D.

EDWARD CHAUM, M.D., Ph.D.

Plough Foundation Professor of Retinal Diseases
Associate Professor

Department of Ophthalmology

Department of Pediatrics

Department of Anatomy and Neurobiology

The University of Tennessee College of Medicine

The University of Tennessee Health Science Center

Hamilton Eye Institute

930 Madison Avenue, Suite 731

Memphis, TN 38163

Tel: (901) 448-5975;

Ph.D. Institution: Department of Cell Biology and Genetics, Cornell Graduate School of Medical Sciences

M.D. Institution: Cornell University Medical College

The focus of the basic science research program in our laboratory is in five major areas:

Translational research in the development and application of gene therapy to the treatment of retina degenerative diseases,
Tissue engineering approaches to understanding and modulating the growth, aging and wound healing responses of ocular retinal pigment epithelial cells (RPE),
Molecular analyses of retinal pigment epithelial cell responses to oxidative stress,
Characterization of a newly discovered IGF binding protein regulatory system in the RPE, and
Tele-ophthalmology and automated diagnostics

Other areas of active research include collaborations on numerous pilot basic science and clinical projects with investigations into:

Genomic analysis of RPE gene expression,
The role of CD81 in proliferative vitreoretinopathy, wound healing and retinal detachment,
The role of Arf gene mutations in the developmental eye anomaly persistent fetal vasculature,
Electrochemical quantification of blood metabolites and drugs, and
Nanotechnology applications in retinal surgery, and
Clinical research studies.

Tobin KW, Chaum E, Govindasamy VP, Karnowski TP. Detection of anatomic structures in human retinal imagery. IEEE Trans Med Imaging. 2007 Dec;26(12):1729-39. PMID: 18092741
Tobin KW, Abdelrahman M, Chaum E, Govindasamy V, Karnowski TP. A probabilistic framework for content-based diagnosis of retinal disease. Conf Proc IEEE Eng Med Biol Soc. 2007;2007:6744-7. PMID: 18003575
Karnowski TP, Govindasamy VP, Tobin KW Jr, Chaum E. Locating the optic nerve in retinal images: comparing model-based and Bayesian decision methods. Conf Proc IEEE Eng Med Biol Soc. 2006;1:4436-9. PMID: 17945838
Yang H, Yang X, Lang JC, Chaum E. Tissue culture methods can strongly induce immediate early gene expression in retinal pigment epithelial cells. J Cell Biochem. 2006 Aug 15;98(6):1560-9. PMID: 16552722
Chaum E, Fawzi A, Chang TS, Shah GK. Diagnostic and therapeutic challenges. Retina. 2006 Feb;26(2):219-22. No abstract available. PMID: 16467682
Ashmore ED, Kerr NC, Greenwald MA, Chaum E. Natural history of acquired retinal oxalosis in a child. J Pediatr Ophthalmol Strabismus. 2004 Sep-Oct;41(5):308-11. PMID: 15478745