JAMES I. MORGAN, Ph.D.

Member and Co-Chairman

Department of Developmental Neurobiology

St. Jude Children's Research Hospital

Affiliated Professor

Department of Anatomy and Neurobiology

The University of Tennessee College of Medicine

Address

St. Jude Children's Research Hospital

MS123, Room D2025E

332 N. Lauderdale

Memphis, TN 38105

Tel: (901) 495-2258; Fax: (901) 495-3143;

Education

Ph.D. Institution: University of Aston, Birmingham, England

Postdoctoral: Max Planck Institute, Tubingen, Germany

Research Interests

The research in this laboratory is aimed at providing an understanding of the molecular basis of neuronal death and regeneration. Using the tools of contemporary molecular biology and genomics, the basis question that is addressed is what moleculars or mechanisms determine whether a nerve cell will die or regenerate. In particular, we have focused upon how alterations in gene expression contribute to these reciprocal processes. It is hoped that by elucidating the properties of nerve cells that can successfully regenerate, we can develop new therapeutic strategies to treat a range of human pathophysiological conditions. These range from ameliorating the neurological deficits that infants suffer from perinatal hypoxia-ischemia or cranial irradiation for brain tumors to reversing or preventing the loss of function in individuals who have received head or spinal cord trauma.

Links

St Jude Faculty - James I. Morgan

Recent Publications

• Maguire AM, High KA, Auricchio A, Wright JF, Pierce EA, Testa F, Mingozzi F, Bennicelli JL, Ying GS, Rossi S, Fulton A, Marshall KA, Banfi S, Chung DC, Morgan JI, Hauck B, Zelenaia O, Zhu X, Raffini L, Coppieters F, De Baere E, Shindler KS, Volpe NJ, Surace EM, Acerra C, Lyubarsky A, Redmond TM, Stone E, Sun J, McDonnell JW, Leroy BP, Simonelli F, Bennett J. Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial. Lancet. 2009 Nov 7;374(9701):1597-605. Epub 2009 Oct 23. PMID: 19854499
• Morgan JI, Hunter JJ, Merigan WH, Williams DR. The Reduction of Retinal Autofluorescence Caused by Light Exposure. Invest Ophthalmol Vis Sci. 2009 Jul 23; [Epub ahead of print] PMID: 19628734
• Wei P, Rong Y, Li L, Bao D, Morgan JI. Characterization of trans-neuronal trafficking of Cbln1. Mol Cell Neurosci. 2009 Jun;41(2):258-73. Epub 2009 Apr 1. PMID: 19344768
• Miura E, Matsuda K, Morgan JI, Yuzaki M, Watanabe M. Cbln1 accumulates and colocalizes with Cbln3 and GluRdelta2 at parallel fiber-Purkinje cell synapses in the mouse cerebellum. Eur J Neurosci. 2009 Feb;29(4):693-706. PMID: 19250438
• Morgan JI, Dubra A, Wolfe R, Merigan WH, Williams DR. In vivo autofluorescence imaging of the human and macaque retinal pigment epithelial cell mosaic. Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1350-9. Epub 2008 Oct 24. PMID: 18952914
• Iscru E, Serinagaoglu Y, Schilling K, Tian J, Bowers-Kidder SL, Zhang R, Morgan JI, DeVries AC, Nelson RJ, Zhu MX, Oberdick J. Sensorimotor enhancement in mouse mutants lacking the Purkinje cell-specific Gi/o modulator, Pcp2(L7). Mol Cell Neurosci. 2009 Jan;40(1):62-75. Epub 2008 Oct 1. PMID: 18930827

view complete list of references (pubmed link)