JAMES I. MORGAN, Ph.D.

Member and Co-Chairman

Department of Developmental Neurobiology

St. Jude Children's Research Hospital

Affiliated Professor

Department of Anatomy and Neurobiology

The University of Tennessee College of Medicine

Address

St. Jude Children's Research Hospital

MS123, Room D2025E

332 N. Lauderdale

Memphis, TN 38105

Tel: (901) 495-2258; Fax: (901) 495-3143;

Education

Ph.D. Institution: University of Aston, Birmingham, England

Postdoctoral: Max Planck Institute, Tubingen, Germany

Research Interests

The research in this laboratory is aimed at providing an understanding of the molecular basis of neuronal death and regeneration. Using the tools of contemporary molecular biology and genomics, the basis question that is addressed is what moleculars or mechanisms determine whether a nerve cell will die or regenerate. In particular, we have focused upon how alterations in gene expression contribute to these reciprocal processes. It is hoped that by elucidating the properties of nerve cells that can successfully regenerate, we can develop new therapeutic strategies to treat a range of human pathophysiological conditions. These range from ameliorating the neurological deficits that infants suffer from perinatal hypoxia-ischemia or cranial irradiation for brain tumors to reversing or preventing the loss of function in individuals who have received head or spinal cord trauma.

Links

St Jude Faculty - James I. Morgan

Recent Publications

• Pattarini R, Rong Y, Qu C, Morgan JI. Distinct mechanisms of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine resistance revealed by transcriptome mapping in mouse striatum. Neuroscience. 2008 Sep 9;155(4):1174-94. Epub 2008 Jul 8. PMID: 18675323
• Morgan JI, Hunter JJ, Masella B, Wolfe R, Gray DC, Merigan WH, Delori FC, Williams DR. Light-induced retinal changes observed with high-resolution autofluorescence imaging of the retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3715-29. Epub 2008 Apr 11. PMID: 18408191
• Wei P, Smeyne RJ, Bao D, Parris J, Morgan JI. Mapping of Cbln1-like immunoreactivity in adult and developing mouse brain and its localization to the endolysosomal compartment of neurons. Eur J Neurosci. 2007 Nov;26(10):2962-78. PMID: 18001291
• Pattarini R, Smeyne RJ, Morgan JI. Temporal mRNA profiles of inflammatory mediators in the murine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine model of Parkinson's disease. Neuroscience. 2007 Mar 16;145(2):654-68. Epub 2007 Jan 29. PMID: 17258864
• Bao D, Pang Z, Morgan MA, Parris J, Rong Y, Li L, Morgan JI. Cbln1 is essential for interaction-dependent secretion of Cbln3. Mol Cell Biol. 2006 Dec;26(24):9327-37. Epub 2006 Oct 9. PMID: 17030622
• Wang T, Parris J, Li L, Morgan JI. The carboxypeptidase-like substrate-binding site in Nna1 is essential for the rescue of the Purkinje cell degeneration (pcd) phenotype. Mol Cell Neurosci. 2006 Oct;33(2):200-13. Epub 2006 Sep 6. PMID: 16952463

view complete list of references (pubmed link)