JENA J. STEINLE, Ph.D.

Associate Professor

Department of Ophthalmology

Department of Anatomy and Neurobiology

Hamilton Eye Institute

The University of Tennessee College of Medicine

Address

The University of Tennessee Health Science Center

930 Madison Ave, Suite 722A

Memphis, TN 38163

Tel: (901) 448-1910; Fax: (901) 448-5028;

Education

Ph.D. Institution: University of Kansas Medical Center, Kansas City, KS

Postdoctoral: Texas A&M University Health Science Center, Temple, TX

Research Interests

Research in our lab investigates changes in the choroid and retina in age-related macular degeneration and diabetic retinopathy. We are currently working on the effects of loss in sympathetic innervation (the fight or flight system) on the retinal pathology associated with diabetic retinopathy and choroidal pathology with macular degeneration. We use modern cellular and molecular biology techniques on cell culture and animal samples to evaulate the mechanisms for the disease processes. We are also interested in the interactions between sympathetic nerves and the vasculature they innervate.

Recent Publications

• Panjala SR, Thomas SA, Steinle JJ. Effects of insulin-like growth factor-1 (IGF-1) receptor signaling on rates of apoptosis in retina of dopamine beta hydroxylase (Dbh(-/-)) knockout mice. Auton Neurosci. 2009 Sep 11; [Epub ahead of print] PMID: 19748322
• Jiang Y, Walker RJ, Steinle JJ. Age-associated increase in cleaved caspase 3 despite phosphorylation of IGF-1 receptor in the rat retina. J Gerontol A Biol Sci Med Sci. 2009 Nov;64(11):1154-9. Epub 2009 Aug 20. PMID: 19696229
• Williams KP, Steinle JJ. Maintenance of beta-adrenergic receptor signaling can reduce Fas signaling in human retinal endothelial cells. Exp Eye Res. 2009 Oct;89(4):448-55. Epub 2009 Jun 11. PMID: 19523948
• Steinle JJ, Sharma S, Smith CP, McFayden-Ketchum LS. Normal aging involves modulation of specific inflammatory markers in the rat retina and choroid. J Gerontol A Biol Sci Med Sci. 2009 Mar;64(3):325-31. Epub 2009 Jan 30. PMID: 19181710
• Steinle JJ, Kern TS, Thomas SA, McFadyen-Ketchum LS, Smith CP. Increased basement membrane thickness, pericyte ghosts, and loss of retinal thickness and cells in dopamine beta hydroxylase knockout mice. Exp Eye Res. 2009 Jun;88(6):1014-9. Epub 2009 Jan 7. PMID: 19176214
• Steinle JJ, Cappocia FC Jr, Jiang Y. Beta-adrenergic receptor regulation of growth factor protein levels in human choroidal endothelial cells. Growth Factors. 2008 Dec;26(6):325-30. PMID: 19021032

view complete list of references (pubmed link)