KAFAIT U. MALIK, D.Sc., Ph.D.

Professor

Department of Pharmacology

The University of Tennessee College of Medicine

Address

The University of Tennessee Health Science Center

216 Crowe Research Building

874 Union Avenue

Memphis, TN 38163

Tel: (901) 448-6075; Fax: (901) 448-7300;

Education

D.Sc. Institution: University of Zagreb, Department of Pharmaceutics, Zagreb, Yugoslavia

Ph.D. Institution: University of Sarajevo, Department of Pharmacology, Sarajevo, Yugoslavia

Postdoctoral: University of Mainz, Department of Pharmacology, Mainz, W. Germany; University of Ottawa, Department of Pharmacology, Ottawa, Ontario

Research Interests

The objective of the research in this laboratory is to investigate the regulation of adrenergic neuroeffector events in the cardiovascular system. A variety of physiological, pharmacological, cellular and molecular techniques are used to define interaction of these neurohormonal systems in several experimental preparations of different species, both in vitro and in vivo.

The specific aims are: 1) characterization of receptors and the underlying signal transduction mechanisms (coupling of receptors to phospholipases via different G proteins) involved in adrenergically-induced release of arachidonic acid for prostaglandin synthesis; 2) investigation of the mechanism of action of arachidonic acid metabolites on release of the adrenergic transmitter ; and 3) examination of the mechanism of interaction of angiotensins and adrenergic nervous system in the regulation of cardiovascular function.

Links

Pharmacology - Kafait U. Malik

Recent Publications

• Mugabe BE, Yaghini FA, Song CY, Buharalioglu CK, Waters CM, Malik KU. Angiotensin II-Induced Migration of Vascular Smooth Muscle Cells is Mediated by p38-MAPK Activated c-Src Through Spleen Tyrosine Kinase and EGFR Transactivation. J Pharmacol Exp Ther. 2009 Oct 1; [Epub ahead of print] PMID: 19797620
• Lavrentyev EN, Malik KU. High glucose-induced Nox1-derived superoxides downregulate PKC-betaII, which subsequently decreases ACE2 expression and ANG(1-7) formation in rat VSMCs. Am J Physiol Heart Circ Physiol. 2009 Jan;296(1):H106-18. Epub 2008 Oct 31. PMID: 18978194
• Tunctan B, Yaghini FA, Estes A, Malik KU. Prostaglandins inhibit cytochrome P450 4A activity and contribute to endotoxin-induced hypotension in rats via nitric oxide production. Arch Pharm Res. 2008 Jul;31(7):856-65. Epub 2008 Aug 14. PMID: 18704327
• Tunctan B, Korkmaz B, Buharalioglu CK, Firat SS, Anjaiah S, Falck J, Roman RJ, Malik KU. A 20-hydroxyeicosatetraenoic acid agonist, N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats. Shock. 2008 Sep;30(3):329-35. PMID: 18323740
• Pavicevic Z, Leslie CC, Malik KU. cPLA2 phosphorylation at serine-515 and serine-505 is required for arachidonic acid release in vascular smooth muscle cells. J Lipid Res. 2008 Apr;49(4):724-37. Epub 2008 Jan 9. PMID: 18187403
• Lavrentyev EN, Estes AM, Malik KU. Mechanism of high glucose induced angiotensin II production in rat vascular smooth muscle cells. Circ Res. 2007 Aug 31;101(5):455-64. Epub 2007 Jul 12. PMID: 17626897

view complete list of references (pubmed link)