PETER JOHN MCKINNON, Ph.D.

Member

Department of Genetics and Tumor Cell Biology

St. Jude Children's Research Hospital

Affiliated Associate Professor

Department of Anatomy and Neurobiology

The University of Tennessee College of Medicine

Address

St. Jude Children's Research Hospital

262 Danny Thomas Place
Memphis, TN 38105
Phone (901) 595-2700; Fax (901) 525-6035

Education

Ph.D. Institution: The Flinders Universiry of South Australia, Adelaide, Australia

Postdoctoral: The Roche Institute of Molecular Biology, Nutley, New Jersey

Research Interests

Our goal is to understand the role of the DNA damage response in the nervous system, and how this functions to prevent disease. The response to genotoxic stress is a prerequisite for development of the nervous system. Mutations in a variety of DNA damage-response factors can lead to human diseases that are characterized by pronounced neuropathology. In many of these syndromes the neurological component is amongst the most deleterious aspects of the disease. Because the nervous system poses a particular challenge in terms of clinical intervention, understanding how DNA repair deficiency impacts the nervous system will be important for design of therapies targeted at ameliorating neuropathology including neurodegeneration and brain tumors. For more information please see: http://www.stjude.org/mckinnon

Links

St Jude Faculty - Peter John McKinnon

Recent Publications

• Lee Y, Katyal S, Li Y, El-Khamisy SF, Russell HR, Caldecott KW, McKinnon PJ. The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. Nat Neurosci. 2009 Aug;12(8):973-80. Epub 2009 Jul 26. PMID: 19633665
• Murga M, Bunting S, Montaña MF, Soria R, Mulero F, Cañamero M, Lee Y, McKinnon PJ, Nussenzweig A, Fernandez-Capetillo O. A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat Genet. 2009 Aug;41(8):891-8. Epub 2009 Jul 20. PMID: 19620979
• Kondo N, Takahashi A, Mori E, Ohnishi K, McKinnon PJ, Sakaki T, Nakase H, Ohnishi T. DNA ligase IV as a new molecular target for temozolomide. Biochem Biophys Res Commun. 2009 Oct 2;387(4):656-60. Epub 2009 Jul 15. PMID: 19615340
• Lee Y, McKinnon PJ. Detection of apoptosis in the central nervous system. Methods Mol Biol. 2009;559:273-82. PMID: 19609763
• Dewire MD, Ellison DW, Patay Z, McKinnon PJ, Sanders RP, Gajjar A. Fanconi anemia and biallelic BRCA2 mutation diagnosed in a young child with an embryonal CNS tumor. Pediatr Blood Cancer. 2009 Dec;53(6):1140-2. PMID: 19530235
• El-Khamisy SF, Katyal S, Patel P, Ju L, McKinnon PJ, Caldecott KW. Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin. DNA Repair (Amst). 2009 Jun 4;8(6):760-6. Epub 2009 Mar 19. PMID: 19303373

view complete list of references (pubmed link)