STEVEN J. TAVALIN, Ph.D.

Associate Professor

Department of Pharmacology

The University of Tennessee College of Medicine

Address

The University of Tennessee Health Science Center

2105 Crowe Research Building

874 Union Avenue

Memphis, TN 38163

Tel: (901) 448-3007;

Education

Ph.D. Institution: Medical College of Virginia, Virginia Commonwealth University, Richmond, VA

Postdoctoral: Vollum Institute, Oregon Health Sciences University, Portland, OR

Research Interests

How do neurons modify their behavior in response to patterns of activity? To address this question my research employs a combination of biochemical, and electrophysiological techniques. Specifically, I am interested in understanding the mechanisms by which intracellular signalling enzymes are directed towards ion channels to allow modulation of channel activity and its impact on excitatory transmission and neuronal excitability.

Links

Pharmacology - Steven J. Tavalin

Recent Publications

• Nikandrova YA, Jiao Y, Baucum AJ, Tavalin SJ, Colbran RJ. CaMKII binds to and phosphorylates a specific SAP97 splice variant to disrupt association with AKAP79/150 and modulate AMPAR activity. J Biol Chem. 2009 Oct 26; [Epub ahead of print] PMID: 19858198
• Liang Y, Tavalin SJ. Auxiliary beta subunits differentially determine pka utilization of distinct regulatory sites on Cav1.3 L type Ca2+ channels. Channels (Austin). 2007 Mar-Apr;1(2):102-12. Epub 2007 Apr 12. PMID: 18690020
• Tavalin SJ. AKAP79 selectively enhances protein kinase C regulation of GluR1 at a Ca2+-calmodulin-dependent protein kinase II/protein kinase C site. J Biol Chem. 2008 Apr 25;283(17):11445-52. Epub 2008 Feb 27. PMID: 18305116
• Gardner LA, Tavalin SJ, Goehring AS, Scott JD, Bahouth SW. AKAP79-mediated targeting of the cyclic AMP-dependent protein kinase to the beta1-adrenergic receptor promotes recycling and functional resensitization of the receptor. J Biol Chem. 2006 Nov 3;281(44):33537-53. Epub 2006 Aug 28. PMID: 16940053
• Pérez-Otaño I, Luján R, Tavalin SJ, Plomann M, Modregger J, Liu XB, Jones EG, Heinemann SF, Lo DC, Ehlers MD. Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1. Nat Neurosci. 2006 May;9(5):611-21. Epub 2006 Apr 16. PMID: 16617342
• Tavalin SJ, Shepherd D, Cloues RK, Bowden SE, Marrion NV. Modulation of single channels underlying hippocampal L-type current enhancement by agonists depends on the permeant ion. J Neurophysiol. 2004 Aug;92(2):824-37. Epub 2004 Mar 31. PMID: 15056682

view complete list of references (pubmed link)